This project falls under the research topics of protein structure, dynamics, function, and biophysical chemistry.The main focus of this project is to elucidate the secondary structure of a viral bacteriophage protein from the ΦKT podoviridae that infects E.coli bacteria. The protein of interest is the gp28 endolysin protein that most likely functions to break the […]
A56-P: Asymmetric Triazole-Au(I) Enantioselective Catalyze of [4+3] Cycloaddition of Dialkylated Malonate
This project aims to analyze the enantioselective property of triazole-gold(I) catalyst on a dialkylated malonate substrate. Unfortunately, the progress of the experiment was stunted, therefore, the project was not fully able to be completed. The results obtained are shown in the poster. Authors: Andy Storer, Dr. Benjamin Gung Faculty Advisor: Dr. Benjamin Gung, Chemistry and […]
B22-P: Determination of Pinholin S21 TMD1 and TMD2 Helical Tilt Angles using CW EPR
Determining how a protein folds is one of the most difficult problems in biochemistry. One class of proteins are membrane bound proteins. Because a membrane is a difficult environment this class of proteins poses unique challenges to studying their structure. One of the methods that can be used to determine a protein’s folding conformation is […]
C25-P: A Study on the Influence of Nitrogen on the Folding Tendency of Ortho-Phenylenes
Within the field of organic chemistry, the stability of proteins and other organic molecules has always been factored into consideration for most reactions. Focusing on ortho-phenylenes, in this case ortho-sexiphenyl, we wanted to determine the effect of nitrogen substitution on its folding tendency. Polyphenylenes are well-known materials in chemistry due to their chemical stability, inherent conjugation, […]
B10-P: Preparation of Low Molecular Weight Heparins in a Flow System
Enoxaparin is a low molecular weight heparin with an average molecular weight of 4.5 kDa that is used as an anticoagulant. The first continuous flow process was developed to synthesize enoxaparin from heparin benzyl ester via base promoted partial depolymerization. Enoxaparin biosimilars were produced in a 25 minute residence time at 65° C in a […]
A45-P: In Silico Aromatic Expanded o-Phenylene Oligomer: Conformational Behavior
Polyphenylenes are molecules that are composed of benzene rings connected in a repeating pattern. Although extensive research has been done into one group of isomers, para-phenylenes, which is used in polymer chemistry, limited research has been done on the ortho-phenylenes. ortho-Phenylenes are conjugated chains of benzenes that have been found previously to form organized helical […]
C23-P: Nitro Substituent Effects on Conformational Folding Behavior of ortho-Phenylene Hexamers
Oligomers can acquire precise alternate structures that fold into intricate secondary conformations with various functionalities, also known as foldamers. Not until recently has research been conducted on polyphenylenes that possess ortho connectivity compared to polyphenylenes in the para and meta positions. The purpose of our current study is to assemble oP6(NO2)2A, oP6(NO2)4A, oP6(NO2)2B and oP6(NO2)4B […]
A30-P: Structural Determination of Alr1300 in Nostoc sp. PCC 7120: Functional Insights to Pentapeptide Repeat Proteins
Alr1300 is a protein of an unknown structure and function in cyanobacteria, Nostoc sp. PCC 71210. This protein is part of the same gene cluster as alr1298 which is from the pentapeptide class of proteins which is a common structure with an unknown function in cyanobacteria. Since the function of proteins in gene clusters tend […]
C19-P: Analyzing Biodegradation of Tannins in Soil
Tannins are a class of polyphenols that precipitate proteins and quench oxidizing species. Condensed tannins, which are multiple flavonoids linked by carbon-carbon bonds, are present in soil but their metabolic fate and effect on the microbiome is unknown. In this study we analyzed possible trends in condensed tannins biodegradation when microbes are present in the […]
B23-P: Selective Halogenation of 2,6-di(pyrazol-1-yl)pyridine Ligands for [M(L1)2]2+[X]2^2- Spin-Crossover Relaxation Rate Characterization
This work encompasses inorganic and physical chemistry to ask how halogenation of select ligand influences the spin-crossover properties of the Fe and Co complexes. Previous work has shown complexes with spin-crossover transitions at very low temperatures (~200K). This low temperature is not viable for any scalable storage method. There has been a reported complex using […]