This project explores the ability of various compounds to inhibit variants of the New Delhi Metallo-Beta-Lactamase (NDM) enzyme. Metallo-beta-lactamases (MBLs) are enzymatic resistance mechanisms expressed by a growing number of bacteria found to exhibit antibiotic resistance. While other resistance mechanisms can be treated, no clinically-viable inhibitor exists for MBL enzymes. Due to this looming threat, […]
C17: Normal Phase and Reversed Phase Liquid Chromatography Using Dimethylcarbonate as the Mobile Phase Modifier Solvent
A growing focus in the field of green analytical chemistry has been the development of greener solvents. Thus, the idea of replacing toxic solvents used in high performance liquid chromatography (HPLC) has become a priority. Previous work has shown that dimethyl carbonate (DMC) is a useful replacement for acetonitrile in hydrophilic interaction liquid chromatography (HILIC). […]
C34: Engineering an Oncolytic Adenovirus Containing HMGA1-Antisense for Treatment of Pancreatic Cancer
Being one of the major cancers with the highest mortality rate and lowest 5-year survival rate, pancreatic cancer is growingly concerned world-wide. Recurrence rate after surgery is still high. Therefore, safe, affordable, and effective therapies are increasingly needed for a better outcome. The main objective of this project is to engineer an oncolytic adenovirus with […]
C35: Investigating the Role of the Gut Microbiome in the Onset of Type 1 Diabetes
My research is focused on Type 1 diabetes (T1D) and its potential link to the onset of T1D. T1D is an autoimmune disorder with a high prevalence and increasing incidence worldwide. T1D is characterized by a loss of insulin secreting β-cells, which places afflicted individuals at risk of death from complications and decreasing their quality […]
C37: Investigating the Efficiency of Nitrogen Fertilizer
Our research focuses on finding the most efficient fertilizer with the least environmental impact while still producing a high crop yield that incorporates the field of agriculture, environmental studies and business. We conducted our research by searching for information within published work. We used websites like the Web of Science and Google Scholar to find […]
C39: Sustainable Agriculture Project Proposal for Clean Water
Conventional industrial farming practices have greatly reshaped the environment, and some would say for the worst. While these modern practices amass large yields, it results in even greater damage to our soil and ultimately our water. Therefore, we set out to find an alternative to these practices and, through some digging, settled on regenerative agriculture. […]
C41: Synthesis of Copolymers through RAFT Polymerization
Biological macromolecules are some of the most fundamental examples of polymers with controlled sequences. Harnessing these abilities based on biological macromolecules will provide insight into potential synthesis of controlled sequence polymers in chemistry. In the upcoming experiment, block copolymers were synthesized through RAFT polymerization to potentially synthesize polymers with varying architectures and characteristics. The experiment […]
C44: Molecular Chaperone Implicated in Cancer Causation: Investigating the Role of Grp94’s Pre-N Domain
Molecular chaperones are a class of proteins that identify destabilized or misfolded proteins to prevent their aggregation as well as assist them in reaching their native conformations. Heat-shock protein 90 (Hsp90) proteins are a class of molecular chaperones of which Glucose-regulated protein 94 (Grp94) is the endoplasmic reticulum paralog. While Grp94 is responsible for the […]
C61: A Growing Library of Co(II) Coordination Complexes
Previous studies have looked at Fe(II) coordination complexes that are present in biological enzymes. These studies have explored the nature of the coordination complexes and relate the structure to spectroscopic techniques. A particular area of interest is high spin coordination complexes in which there are several unpaired electrons all going in the same direction. This […]
C69: Engineering CRISPR-Cas For Rapid, Sensitive, and Selective Analytical Sensing
The COVID-19 pandemic has brought to light the importance of diagnostics in detecting and containing infectious diseases. Recently, a new class of CRISPR-Cas enzymes, known as Cas12, has been discovered and utilized as a biosensor to detect nearly any genetic biomarker of interest. Cas12 is similar to other CRISPR-Cas proteins, in that it forms an […]