Bulk water is an essential component for dissolution-the process in which ionic compounds are broken down into constituent charged species. Water solvates ions, engages in hydrogen bonding, exerts electrostatic forces, and contributes to the effects of entropy and enthalpy. Despite bulk water’s importance, its submicroscopic presence is often omitted from high school instructors’ pedagogical practices. […]
B21-P: Complementarity of Endoplasmic Reticulum and Bacterial Molecular Chaperones
This project is in the area of biochemistry and addresses research into prevention of protein aggregation-based diseases such as Alzheimer’s. In cells, molecular chaperones assist with correcting protein folding to prevent diseases caused by misfolded protein aggregation. Cochaperones stimulate and enhance chaperone activity by facilitating client protein presentation and ATP hydrolysis. Heat shock proteins (Hsps) […]
A07-P: Using a Machine Learning Approach to Identify Potential Metallo-β-Lactamase Inhibitors
This project combines the fields of biochemistry and data science by applying a machine learning approach to the identification of potential metallo-β-lactamase (MBL) inhibitors. MBLs are enzymes expressed by antibiotic-resistant bacteria and are becoming more clinically prevalent, leading to an increasing number of severe cases of once easily-treatable infections. In recent years, there has been […]
C10-P: Micellar and Sub-Micellar Chromatography with a Cocamidopropyl Betaine Surfactant
In the past two decades, green analytical chemistry has started to become a more prominent subarea of green chemistry, particularly in the area of sample preparation such as extraction. In typical reversed phase liquid chromatography (LC) methods, organic solvents such as acetonitrile (MeCN) or methanol are used as mobile phase modifiers due to their low […]
C08-P: Qualitative Identification of Transition Metals at the ppm Level using Precipitation Chemistry and Digital Microscopy
In this qualitative experiment the researchers bring back classic precipitation chemistry on various transition metal ion solutions (Ni2+, Pb2+, Co2+) at very low concentrations. Nickel can be precipitated as a red dimethylglyoxime complex, cobalt as a reddish-brown 2-nitroso-1-naphthol complex, and lead as a yellow iodide compound. As this is a qualitative experiment color will be […]
A51-P: How Well do YouTube and Chemistry Mix? Evaluating Educational Videos with Mayer’s Multimedia Principles
YouTube videos are being used as an instructional support to lectures for students, especially in science subjects such as chemistry. A method was developed to quantitatively rate popular acid-base and bonding YouTube videos using Richard Mayer’s seven Multimedia Principles as a framework. A second method was developed to quantitatively rate the videos to specifically investigate […]
C07-P: Hcf106 and cpTatC Fusion Overexpression and Purification Using Liquid Chromatography
The twin-arginine protein translocation system (Tat) is a membrane-bound protein complex that transports folded proteins across the thylakoid membranes in plants and cytoplasmic membranes in bacteria. It is predicted that about 50% of the thylakoid lumen proteins use the cpTat pathway. For a precursor to pass the thylakoid membrane under this system, involves the association […]
C20-P: Methods for Tannin Purification, Quantitative and Qualitative Analysis, and Quality Control
Tannins are plentiful in plant based foods. Due to their unique chemistry, they have important effects on the health of humans and other animals. However, the tannin itself is not absorbed; rather, the gut microbiome breaks it down and its decomposition products are absorbed. This makes studying the effects of dietary tannins difficult. To combat […]
C06-P: MBLinhibitors.com, a Website Resource Offering Information and Expertise for the Continued Development of Metallo-β-Lactamase Inhibitors
Metallo-β-Lactamases are enzymes that bacteria produce to protect themselves from various β-Lactam antibiotics. As a result of the growing antibiotic resistance crisis, new compounds have been developed to try to inhibit these enzymes and slow the spread of antibiotic resistance. In an effort to facilitate the discovery of new, improved inhibitors of the metallo-β-lactamases, a […]
A31-P: Computational Analysis of the Structure of Fluorinated o-Phenylenes
Ortho-Phenylenes have been found to take on conformations similar to those found in biological secondary structures, classifying them as a type of molecule known as foldamers. The goal of studying this class of molecules is to eventually use this simple structure in 3D molecules that mimic biological systems. Past studies have been done to investigate […]