Heat shock protein 90 (Hsp90) is an extremely abundant molecular chaperone. Hsp90 has roles in the folding and reactivation of hundreds of client proteins. Chaperones like Hsp90 complete their protein remodeling activities using energy generated from ATP hydrolysis. To complete the protein folding process, Hsp90 collaborates with many other co-chaperones, including the Hsp70 chaperone system. […]
C18: The Final Straw: Microplastics and Water Purification Talk
Microplastics are becoming a substantial problem in our environment. Although a definition for microplastics has not yet been formalized, the scientific community agrees that plastic particles within the size range of millimeter to sub-millimeter are considered microplastics. As plastic production has expanded greatly in recent years, more and more microplastics have begun to take over […]
C24: Purification and Characterization of Human KCNQ1 (100-370), a Voltage Gated Potassium Ion Channel, in Lipid Bilayers Using Solid-State NMR; Human KCNQ1 (100-370)/KCNE1 Interaction Studies Using EPR
KCNQ1 (Q1 or Kv7.1 or KvLQT1) is a membrane bound voltage gated potassium channel that is modulated by another membrane protein KCNE1 (E1). Q1 is an integral protein involved in the cardiac repolarization phase of a heartbeat following the action potential. E1 is an accessory protein that complexes with Q1 to form a 4:2 Q1:E1 […]
A17: Combating Antibiotic Resistance
Our research group has been studying the effects of antibiotic resistance in our society. We chose to study this topic because it is a major issue that is affecting people all over the world. Our research project involved us learning about antibiotics from the beginning; when they were first produced, how they work, why bacteria […]
B24: Characterization of high molecular weight polyphenols by FT-ICR MALDI-MS and HPLC
Condensed tannins are high molecular weight polymers, comprised of flavan-3-ol monomers stabilized by C-C interflavan bonds. Condensed tannins are found in most higher plants, and affect food properties such as astringency and protein availability, N- and C-cycles in soil systems, and agronomic properties such as insect and pathogen resistance. Tannins are highly sorptive molecules, making […]
C27: Cosmetics in the Forensic Field
This project examined the application of a forensic analysis of cosmetics for the undergraduate teaching laboratory using infrared spectroscopic and microscopic techniques. Samples analyzed included known cosmetic ingredients, open cosmetic containers, a suspect’s t-shirt with a makeup smudge, and a cotton swab sample taken from the victim’s face. These samples were characterized by FTIR and […]
B20: Synthesis, Identification, and Characterization of Co(II) Spin Crossover Complexes
Spin Crossover (SCO) Complexes are coordination complexes that exhibit huge changes in magnetic properties under external stimulus, and thus this abrupt change attracted attentions to be studied. This shift in property is a result of transition of the center metal between high-spin and low-spin states, which are two electronic states of the d orbital in […]
C23: Probing human KCNE1 dynamics in various novel nanodiscs using continuous wave- electron paramagnetic resonance spectroscopy (CW-EPR)
Characterizing membrane proteins using biophysical techniques remains a challenge due to maintaining the structural integrity of the membrane protein in vitro. Recently, a novel membrane mimetic system has come of age where an amphiphilic copolymer, styrene-maleic acid (SMA), is added to heterogeneous lipid bilayers to form small homogeneous discs (~10 nm) called styrene-maleic acid copolymer […]
C21: Orthogonal Strategies for the Photochemical Synthesis of Well-Defined Bifunctional Bioconjugates
By attaching polymers to specific sites along a protein, bioconjugation presents an opportunity to increase the functionality of proteins. Bioconjugates have exhibited greater thermal and chemical stability, substrate affinity, and serum half-life. By adding two different polymers to a protein, bifunctional bioconjugation allows for greater control over the functionality of the protein, increasing the stability […]
C28: Combatting Antibiotic Resistance: Structural Characterization of VIM and NDM Mutants
Antibiotics have been essential to the development of modern medical practices and are often used as the first line of defense in most illnesses. However, a cause of increasing problems and concerns in the medical community is the development of antibiotic-resistance mechanisms in pathogenic bacteria. Some of the most worrying enzymes to emerge are metallo-beta-lactamases […]
You must be logged in to post a comment.