Carbodiimide-driven anhydride formation from carboxylic acids is useful in a variety of non-equilibrium systems. While there are multiple strategies to control deactivation (anhydride hydrolysis) rates, control over activation (anhydride formation) rates is limited. We show that pyridine derivatives reversibly form adducts with 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide methiodide in water. These adducts are unreactive with carboxylic acids and thus […]
A15: Molecular Mechanism of Substrate Protein Recognition and Protein Remodeling by E. coli Hsp90 Molecular Chaperone
Proteins are biological macromolecules that serve a variety of roles in the body, such as providing structural support, transporting molecules around the body, supporting immune function, and facilitating muscle contraction. For these proteins to perform their role, they must fold properly. Some proteins fold spontaneously while others require the help of specialized proteins known as […]
A21: Condensed Tannin Characterization by Modified Saw Tooth HPLC System
Author(s): Kathyrn Williams, Chemistry Major Advisor(s): Ann Hagerman, Department of Chemistry and Biochemistry
A22: Does Condensed Tannin Protect Zein Nanoparticles From Digestion?
Zein, the primary storage protein found in corn (maize) grain, forms nanoparticles on a carbonate scaffold under anti-solvent conditions. These zein nanoparticles may be useful for drug delivery systems but the instability and digestibility of the particles limits their potential use. Tannins are high molecular weight polyphenols made by a variety of plants in leaves, […]
A26: Viability of Boron Doped Diamond Electrode in Concentrated Solar Power System
Author(s): Genevieve Gerenz, Chemistry Major Advisor(s): Cory Rusinek, Department of Chemistry and Biochemistry
A27: Investigating the Infection Biology of Group B Rotavirus
Rotavirus (RV) is a pathogen that causes gastroenteritis in humans and animals. Although there are A-G types of rotavirus, type A (RVA) is the most commonly studied because it is the leading cause of death in children under 5 years averaged with 200,000 deaths a year. Understanding the infection biology of group B rotavirus (RVB) […]
A32: Using On-Column Amide Reactions for Functional Group Identification by Gas Chromatography
Gas chromatography (GC) with flame ionization detection (FID) is still an important and relatively inexpensive problem solving analytical method despite the maturity of this technique. Although the FID is a sensitive and rugged detector, it does not provide qualitative identification of the separated components. We have initiated a dynamic GC stationary phase modification research program […]
A33: Foldamer Synthesis and Potential Applications
The general area our lab researches is organic chemistry. The purpose of our research is to create a foldamer capable of switching on in the presence of a chemical fuel. A foldamer is a discrete chain molecule that folds into a conformationally ordered state in solution. They are artificial molecules that mimic the ability of […]
A34: Determining the Function of Pentapeptide Repeat Proteins in Cyanobacteria During Diurnal Light Cycling and Nitrogen Starvation
Cyanobacteria, among the oldest organisms on Earth, played a crucial role in the development of complex life by oxygenating the Earth’s atmosphere. Cyanobacteria are promising candidates for use in biotechnology applications, including the production of biofuels, pharmaceuticals, and other valuable chemicals, so studying these organisms can result in new ways to harness their potential. By […]
A35: Investigating the Role Gut Microbes Play in Triggering Type 1 Diabetes
Type 1 diabetes (T1D) is an incurable autoimmune disease that drastically affects one’s life. People who have T1D do not make insulin or do not make enough of it. This is due to a deficiency in pancreatic ꞵ-cells. The gut microbiome contains many microbes within it. Some microbes such as Bacteriodetes and Firmicutes are hypothesized […]