Heavy alcohol use and binge drinking are important contributors to alcohol use disorder (AUD). The endogenous opioid system has been implicated in alcohol consumption and preference in both humans and animals. The mu opioid receptor (MOR) is expressed on multiple cells in the striatum, however little is known about the contributions of specific MOR populations […]
A22: Impact of Nicotine and Alcohol Individually and Concurrently in ChAT-MOR Knockout Mice
Alcohol and nicotine are common substances that impact individuals individually and concurrently. This project aims to investigate the impact of nicotine and alcohol in ChAT-MOR mice individually and concurrently. Nicotine and ethanol both affect dopamine release through different mechanisms. We are specifically studying the impact of cholinergic interneurons on dopamine release within the striatum. CHAT-MOR […]
C14: The Effects of Early Life Stress on Alcohol Drinking Behavior in Mice
Alcohol use disorder (AUD) is a complex psychiatric disorder affected by both genetic and environmental factors (Mayfield et al., 2008; Tawa et al., 2016; Young-Wolff et al., 2011). One such environmental variable that strongly correlates to the development of AUD and alcohol abuse is early life stress (ELS) (Guinle & Sinha, 2020; Sinha, 2001). ELS […]
B25: Effects of Adolescent Lorazepam Exposure on Alcohol Drinking Behavior in Adulthood
My general research area is adolescent drug exposure and its long-term consequences. For this study, I investigated the effects of adolescent exposure to benzodiazepines (BZDs) on alcohol intake, preference, and neural response to alcohol in adulthood. This is important for the field because although adolescent alcohol exposure has been thoroughly researched, the long-term effects of […]
C49: Effects of Adolescent Benzodiazepine Exposure on Alcohol Intake and Tolerance
Benzodiazepines (BZDs) are strong anxiolytic drugs that act at GABA receptors, resulting in overall inhibition of the central nervous system (CNS). Benzodiazepines can be prescribed by a doctor, or recreationally abused. One in five high schoolers report using benzodiazepines either medically or recreationally. However, the longitudinal effects of benzodiazepine use during adolescence have not been […]
A19-P: Introduction to Neuroscience Class Project: Group 4
The objective of this class, Introduction to Neuroscience: BIO 159, is to familiarize students with common methodologies and techniques that are used in the field of Neuroscience. In small groups that were divided upon specific topics of interest, students were prompted to explore popular news articles that communicate neuroscience research to a public audience. In […]
A16-P: Exploring Dr Radke’s Reward and Addiction Lab
This is a project for Seminar in Neuroscience regarding the RAD Lab. The Reward and Addictive Disorder (RAD) Lab is a research lab at Miami University that makes use of mice in order to study compulsive and reward-seeking behavior. More specifically, the RAD Lab seeks to study changes in brain function associated with maladaptive behaviors […]
C89: American Opioid Crisis: An Assay of Opioid Addiction and Treatment
Opioid use disorder is a widespread issue in the United States in need of immediate attention. Over 11.5 million Americans reported having misused opioids in 2016, typically to alleviate chronic pain. By misuse or submission to said pain, people are suffering. Misuse causes addiction, and treatments are sparse, expensive, and sometimes dangerous. It is imperative […]
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