Fragile X Syndrome (FXS) is a leading cause of inherited mental disability and autism spectrum disorders. An increased number of CGG repeats (>200) in the fmr1gene results in a loss of the gene’s protein product, Fragile X Mental Retardation Protein (FMRP), resulting in neural deficits and impaired learning and social behaviors. Our goal was to […]
B39: Bedrock-topography and Quaternary drift-thickness maps of Oxford and College Corner quadrangles, Butler and Preble counties, Ohio
A collaborative bedrock/surficial deposit mapping project between Miami University and the Ohio Department of Natural Resources (ODNR), Division of Geological Survey has resulted in the generation of a revised bedrock topography map for the Oxford and College Corner 7.5-minute quadrangles, Butler and Preble counties, southwest Ohio. The study area consists of glaciated uplands dissected by […]
C24: Purification and Characterization of Human KCNQ1 (100-370), a Voltage Gated Potassium Ion Channel, in Lipid Bilayers Using Solid-State NMR; Human KCNQ1 (100-370)/KCNE1 Interaction Studies Using EPR
KCNQ1 (Q1 or Kv7.1 or KvLQT1) is a membrane bound voltage gated potassium channel that is modulated by another membrane protein KCNE1 (E1). Q1 is an integral protein involved in the cardiac repolarization phase of a heartbeat following the action potential. E1 is an accessory protein that complexes with Q1 to form a 4:2 Q1:E1 […]
A28: Natural Product Biosynthesis: Evaluation of TrpM Activity
The purpose of my project was to express and measure in vivo activity of the TrpM enzyme in E. coli. TrpM is part of a methylase family of enzymes that adds a methyl group to a base molecule, in the case of TrpM, the base molecule is the aromatic amino acid tryptophan. To do this […]
A23: Biomedical Applications of Sensing Multi-State Metabolic Behavior from Cellular Autofluorescence
One way to detect metabolic change in cells is through a method called laser-induced fluorescence spectroscopy which involves exciting the cellular sample using a laser and measuring the spectrum of its autofluorescence emission. In order to detect metabolic change, we monitor autofluorescence emission in real time, and through past studies we are able to quantify […]
A77: Examining the Impact of Fiber and Added Sugar on Body Fat Percentage, Blood Glucose, and Lipid Levels
Research has demonstrated that fiber has the potential to counteract absorption of glucose and lipids found in high-fiber foods. Fiber has been shown to decrease blood glucose and cholesterol levels, assisting in weight loss efforts. For older adults, fiber intake recommendations are 30g (males) and 21g (females) daily. Daily recommendations include less than 35g (males) […]
A17: Combating Antibiotic Resistance
Our research group has been studying the effects of antibiotic resistance in our society. We chose to study this topic because it is a major issue that is affecting people all over the world. Our research project involved us learning about antibiotics from the beginning; when they were first produced, how they work, why bacteria […]
B47: Physics Education: Introductory Student Self-Efficacy and Problem-Solving Approaches
Physics education research focuses on how to improve the effectiveness of student learning and curriculum development. This area of physics education specifically focuses on students in introductory physics courses and how their self-efficacy and problem-solving methods change over the course of a semester. By tracking the improvement or deterioration of a student’s abilities, the Miami […]
A64: Experience Learning: How to Increase Volunteer Engagement
The MUSCRAT Community Psychology lab works with the Experience program at the Boys and Girls Club of Hamilton to provide guidance for the effectiveness of their programs. This is an organization that depends on volunteers to provide their services. Volunteers are essential to many organizations that serve to help the community. Additionally, there are many […]
C09: Burial Rates of Carbon, Nitrogen, and Phosphorus in Sediments of Three Retention Ponds in a Watershed with Changing Agricultural Practices
Within the area of freshwater science, researching small-scale retention ponds is useful to determine how successful they are at trapping excess sediment, carbon (C), nitrogen (N), and phosphorus (P), which can all have negative environmental effects (such as contributing to global climate change or harmful algal blooms) if left unchecked. The goal of my research […]
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