The general area our lab researches is organic chemistry. The purpose of our research is to create a foldamer capable of switching on in the presence of a chemical fuel. A foldamer is a discrete chain molecule that folds into a conformationally ordered state in solution. They are artificial molecules that mimic the ability of […]
B29: Copper-Catalyzed Deaminative Difluoromethylation
A difluoromethyl group (CF2H) is considered to be a lipophilic and metabolically stable bioisostere of an amino (NH2) group. Therefore, methods that can directly convert a NH2 group into a CF2H group would be of great value to medicinal chemistry. We report an efficient Cu-catalyzed approach for the conversion of alkyl pyridinium salts, which can […]
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