Throughout the course of human civilization, Influenza Viruses A and B— the viruses responsible for causing the majority of cases of influenza— have negotiated a tenuous coexistence with the human population. Yearly, between January and March, 10 to 45 million people in the United States alone contract influenza, causing significant economic and social burdens. Occasionally, […]
B19: Constructing the B Lymphoid Protein Interaction Network of FCRL1
Immunology seeks to investigate the immune system’s response to pathogens and the diseases that result when the immune system is improperly regulated. B cells are immune cells that function to produce antibodies, proteins that target a specific molecule for destruction by the immune system. However, in autoimmune diseases, antibodies may target the host’s body. To […]
A19: Functional and physical interaction between Hsp90 and Hsp70
Heat shock protein 90 (Hsp90) is an extremely abundant molecular chaperone. Hsp90 has roles in the folding and reactivation of hundreds of client proteins. Chaperones like Hsp90 complete their protein remodeling activities using energy generated from ATP hydrolysis. To complete the protein folding process, Hsp90 collaborates with many other co-chaperones, including the Hsp70 chaperone system. […]
A22: The Role of Metabolic Imaging in Cancers and Disease Diagnosis
We are two undergraduate researchers who study metabolic imaging methods with a focus on NAD(P)H conformations. The goal of our research is to review some of the different types of imaging strategies present for monitoring specific data about cellular metabolism. To summarize, we begin to answer the research question “what are the different types of […]
C45: Communicating Research to Public Audiences
The research being conducted in this study is an interdisciplinary project focused on the idea of communication to the public. This is all centered on the question of what skills are needed for researchers to effectively communicate their ideas with the public. The relevance of this study relates to all fields because if researchers are […]
CS1-01: Quantifying Pigmentation in ImageJ of Cisco Fish Exposed to Varying Degrees of UV Radiation
Lake Michigan is becoming more transparent and now has potentially damaging ultraviolet (UV) radiation penetrating to deeper depths of the lake–leading to differential changes in fish abundances. Only fish that have innate mechanisms of protection will be able to mitigate damage from exposure to UV radiation. One way species can reduce damage from UV radiation […]
A44: Improving the Academic Success of Bridges Scholars in STEM Disciplines
Mentoring relationships are important to the academic success of many STEM students across the country. These relationships open up opportunities to participate in labs that can give students the necessary experience to be successful after college. How has Miami University and the Bridges Scholars program contributed to the success of STEM students and how can […]
B05: RNAi of the fmr1 gene of the cricket Acheta domesticus: Impact on male agonistic behavior
Fragile X Syndrome (FXS) is a leading cause of inherited mental disability and autism spectrum disorders. An increased number of CGG repeats (>200) in the fmr1gene results in a loss of the gene’s protein product, Fragile X Mental Retardation Protein (FMRP), resulting in neural deficits and impaired learning and social behaviors. Our goal was to […]
B39: Bedrock-topography and Quaternary drift-thickness maps of Oxford and College Corner quadrangles, Butler and Preble counties, Ohio
A collaborative bedrock/surficial deposit mapping project between Miami University and the Ohio Department of Natural Resources (ODNR), Division of Geological Survey has resulted in the generation of a revised bedrock topography map for the Oxford and College Corner 7.5-minute quadrangles, Butler and Preble counties, southwest Ohio. The study area consists of glaciated uplands dissected by […]
C24: Purification and Characterization of Human KCNQ1 (100-370), a Voltage Gated Potassium Ion Channel, in Lipid Bilayers Using Solid-State NMR; Human KCNQ1 (100-370)/KCNE1 Interaction Studies Using EPR
KCNQ1 (Q1 or Kv7.1 or KvLQT1) is a membrane bound voltage gated potassium channel that is modulated by another membrane protein KCNE1 (E1). Q1 is an integral protein involved in the cardiac repolarization phase of a heartbeat following the action potential. E1 is an accessory protein that complexes with Q1 to form a 4:2 Q1:E1 […]