This research was to study the effects of the size lipid vesicles had on the formation of Styrene Maleic-acid lipid particles (SMALPs) when mixed with Styrene Maleic acid (SMA). this was accomplished by extruding the DMPC vesicles to 100 and 200nm and adding incremental amounts of SMA to the lipids until SMALPs formation was confirmed. […]
C26: Dependency of SMALPS Formation upon Vesicle Size
Despite the significant progress made in resolving membrane protein structures, there are still obstacles to overcome, such as the use of detergent and the protein’s native environment and structure. The use of SMA nanoparticles to form nanodiscs eliminates the use of detergent and provides a native-like environment, providing the best alternative to liposomes and other […]