Carbodiimide-driven anhydride formation from carboxylic acids is useful in a variety of non-equilibrium systems. While there are multiple strategies to control deactivation (anhydride hydrolysis) rates, control over activation (anhydride formation) rates is limited. We show that pyridine derivatives reversibly form adducts with 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide methiodide in water. These adducts are unreactive with carboxylic acids and thus […]
A38: Machine Learning in Organic Chemistry: Improving the Accuracy of Elimination Reaction Predictions
In recent years, machine learning and artificial intelligence has found unique applications in a plethora of fields and industries. Specifically, in organic chemistry, machine learning algorithms have been used to predict organic synthesis strategies based on previous patented data. Although the current available programs have shown over 90% accuracy on many common industrial reactions, they […]
A37: Abiotic Proteins: ortho-Phenylene Based Foldamer Cages
Great progress has been made toward the design of secondary structure in abiotic foldamers. However, to mimic the function and behavior of proteins, well defined tertiary structure must be achieved. The self-assembly of foldamers into macrocyclic cages is a simple approach to tertiary structure. The molecular backbone chosen for our foldamer cages is the ortho-phenylenes. […]