Molecular chaperones are a class of proteins that identify destabilized or misfolded proteins to prevent their aggregation as well as assist them in reaching their native conformations. Heat-shock protein 90 (Hsp90) proteins are a class of molecular chaperones of which Glucose-regulated protein 94 (Grp94) is the endoplasmic reticulum paralog. While Grp94 is responsible for the […]
B21-P: Complementarity of Endoplasmic Reticulum and Bacterial Molecular Chaperones
This project is in the area of biochemistry and addresses research into prevention of protein aggregation-based diseases such as Alzheimer’s. In cells, molecular chaperones assist with correcting protein folding to prevent diseases caused by misfolded protein aggregation. Cochaperones stimulate and enhance chaperone activity by facilitating client protein presentation and ATP hydrolysis. Heat shock proteins (Hsps) […]