B10-P: Preparation of Low Molecular Weight Heparins in a Flow System

Enoxaparin is a low molecular weight heparin with an average molecular weight of 4.5 kDa that is used as an anticoagulant. The first continuous flow process was developed to synthesize enoxaparin from heparin benzyl ester via base promoted partial depolymerization. Enoxaparin biosimilars were produced in a 25 minute residence time at 65° C in a […]

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