The enzyme yeast alcohol dehydrogenase (YADH) is used in the undergraduate biochemistry lab class at Miami University to teach students essential biochemical methods and concepts. Specifically, the students compare the wild type enzyme to overexpressed His-tagged YADH. An experiment was designed for students to monitor protein stability over time using recently “upcycled” HP 8453 UV/Vis […]
C06-P: MBLinhibitors.com, a Website Resource Offering Information and Expertise for the Continued Development of Metallo-β-Lactamase Inhibitors
Metallo-β-Lactamases are enzymes that bacteria produce to protect themselves from various β-Lactam antibiotics. As a result of the growing antibiotic resistance crisis, new compounds have been developed to try to inhibit these enzymes and slow the spread of antibiotic resistance. In an effort to facilitate the discovery of new, improved inhibitors of the metallo-β-lactamases, a […]
B21: Evolutionary Mechanism of Antibiotic Resistance: VIM – 4 Metallo-β-lactamases
Metallo-β-lactamases (MBLs) are a class of proteins contributing to the ongoing but often unrecognized antibiotic resistance crisis, in which many current and most past antibiotics are less effective than when first introduced. These proteins protect bacteria by destroying manmade antibiotics, and have spread worldwide in part due to the selective pressure of antibiotic overprescription. To […]
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