Cancer continues to be a formidable threat to human health as the second leading cause of death in the United States. Many end-stage cancers frequently evolve into multidrug-resistant (MDR) forms, posing significant challenges in treatment design. To combat this, the Mancini Lab has recently devised a new mechanism of action known as Bystander-Assisted Immunotherapy (BAIT). […]
C55: Investigating viral genes as possible sensitizers for drug resistant cancer cells
Chemotherapy and radiation induce cancer cell death through DNA damage; however, the prevalence of drug-resistant cancer presents a substantial treatment barrier. Previous investigations have connected the overexpression of DNA dependent protein kinase (DNA-PK), a crucial enzyme in the DNA damage response (DDR), to chemotherapy resistant cancer cells. There has been much evidence to indicate that […]
A11: Volatile Organic Compounds and Cancer in adults: Cross-sectional Study
Numerous studies have been conducted to determine how exposure to various amounts of VOCs might affect an individual’s health, as well as how VOC analysis can serve as a reliable predictor of several different cancer subtypes. In this cross-sectional study, we intend to investigate the VOCs present in adult urine, a liquid state of matter, […]
C34: Engineering an Oncolytic Adenovirus Containing HMGA1-Antisense for Treatment of Pancreatic Cancer
Being one of the major cancers with the highest mortality rate and lowest 5-year survival rate, pancreatic cancer is growingly concerned world-wide. Recurrence rate after surgery is still high. Therefore, safe, affordable, and effective therapies are increasingly needed for a better outcome. The main objective of this project is to engineer an oncolytic adenovirus with […]
C19: Engineering an Oncolytic Adenovirus to Specifically Target Pancreatic Cancer
Pancreatic cancer remains a disease with an incredibly high mortality rate since it is virtually undetectable in its early stages and is difficult to treat with current therapies in later stages. The gene high mobility group AT-hook 1 (HMGA1) is upregulated in this type of cancer, which increases the resistance to chemotherapy and increases tumor […]
CSIII-01: Uncovering the Newt’s Regenerative Secrets
Over 14 million people in the United States are currently living with cancer, a disease not limited to humans. In fact, several other animals elicit the growth of tumors when exposed to cancer-causing compounds commonly referred to as carcinogens. However, the newt, a type of salamander, can remain cancer-free when exposed to carcinogenic substances at […]
B94: Novel Developments In Cancer Treatment
Cancer is a disease caused by mutations in the DNA and is the second leading cause of death in the United States. There are a variety of different treatments, including radiation, chemotherapy, immunotherapy, targeted therapy, and surgery that are currently being used to eradicate this disease. The current treatments have many societal issues that are […]
A94: Breast Cancer Survivorship Among Indian American Women: Comparison Research Between Indian Women Living in the U.S. and Those Living in India
This study explores to understand the experiences of breast cancer survivorship amongst underrepresented individuals, particularly women of Indian ethnic origin living both in the United States and in India. Many studies in the past have explored the experiences of breast cancer survivorship, though little has been done to explore the factors that contribute to these […]
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