Newts are an exquisite salamander with unique capability of regenerating most of its tissues and organ. Its lens among all other body parts are the most significant, given when original lens is damaged or lost, a new fully functional lens would be regenerated regardless of age or repeated damage. Our research group has been focused […]
B21-P: Complementarity of Endoplasmic Reticulum and Bacterial Molecular Chaperones
This project is in the area of biochemistry and addresses research into prevention of protein aggregation-based diseases such as Alzheimer’s. In cells, molecular chaperones assist with correcting protein folding to prevent diseases caused by misfolded protein aggregation. Cochaperones stimulate and enhance chaperone activity by facilitating client protein presentation and ATP hydrolysis. Heat shock proteins (Hsps) […]
A07-P: Using a Machine Learning Approach to Identify Potential Metallo-β-Lactamase Inhibitors
This project combines the fields of biochemistry and data science by applying a machine learning approach to the identification of potential metallo-β-lactamase (MBL) inhibitors. MBLs are enzymes expressed by antibiotic-resistant bacteria and are becoming more clinically prevalent, leading to an increasing number of severe cases of once easily-treatable infections. In recent years, there has been […]
C07-P: Hcf106 and cpTatC Fusion Overexpression and Purification Using Liquid Chromatography
The twin-arginine protein translocation system (Tat) is a membrane-bound protein complex that transports folded proteins across the thylakoid membranes in plants and cytoplasmic membranes in bacteria. It is predicted that about 50% of the thylakoid lumen proteins use the cpTat pathway. For a precursor to pass the thylakoid membrane under this system, involves the association […]