Metallo-β-Lactamases are enzymes that bacteria produce to protect themselves from various β-Lactam antibiotics. As a result of the growing antibiotic resistance crisis, new compounds have been developed to try to inhibit these enzymes and slow the spread of antibiotic resistance. In an effort to facilitate the discovery of new, improved inhibitors of the metallo-β-lactamases, a […]
B21: Evolutionary Mechanism of Antibiotic Resistance: VIM – 4 Metallo-β-lactamases
Metallo-β-lactamases (MBLs) are a class of proteins contributing to the ongoing but often unrecognized antibiotic resistance crisis, in which many current and most past antibiotics are less effective than when first introduced. These proteins protect bacteria by destroying manmade antibiotics, and have spread worldwide in part due to the selective pressure of antibiotic overprescription. To […]
A17: Combating Antibiotic Resistance
Our research group has been studying the effects of antibiotic resistance in our society. We chose to study this topic because it is a major issue that is affecting people all over the world. Our research project involved us learning about antibiotics from the beginning; when they were first produced, how they work, why bacteria […]
C28: Combatting Antibiotic Resistance: Structural Characterization of VIM and NDM Mutants
Antibiotics have been essential to the development of modern medical practices and are often used as the first line of defense in most illnesses. However, a cause of increasing problems and concerns in the medical community is the development of antibiotic-resistance mechanisms in pathogenic bacteria. Some of the most worrying enzymes to emerge are metallo-beta-lactamases […]
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