Through mutations and horizontal transfer, bacteria has been able to acquire different forms of antibiotic resistance. In particular, bacteria that produce β-lactamases as a result of mutated or acquired genes have the ability to break down the β-lactam ring structure in many common classes of antibiotics (penicillins, carbapenems, monobactams, and cephalosporins). Metallo-β-lactamases, enzymes that confer […]
A72: Study of Factors Associated With E. coli Antibiotic Resistance in Mining Impacted Regions of Southeastern Kentucky and Implications on Stream Health and Risk Assessment
In rural Regions of Appalachia many homes and towns rely on septic systems to dispose of waste. However, for homes that are unable to replace or afford septic systems, many rely instead on Straight pipes which dump raw sewage right into streams and rivers. Well water & spring water sources quickly become contaminated by Escherichia […]
C16: Investigation of Captopril and QDP-1 for Inhibition of NDM Clinical Variants
This project explores the ability of various compounds to inhibit variants of the New Delhi Metallo-Beta-Lactamase (NDM) enzyme. Metallo-beta-lactamases (MBLs) are enzymatic resistance mechanisms expressed by a growing number of bacteria found to exhibit antibiotic resistance. While other resistance mechanisms can be treated, no clinically-viable inhibitor exists for MBL enzymes. Due to this looming threat, […]