For Adenovirus (Ad) to undergo a successful replication cycle, proteins expressed from the early gene region 4 (E4) function in regulating the host’s DNA damage response (DDR). In mutant viruses with a deletion of the E4 region (E4-), one particular DDR kinase — DNA-dependent protein kinase (DNA-PK)— is able to ligate the ends of Ad […]
C08: Predicting Plant Abundance in a Restored Prairie
In restoration ecology it is important to understand the processes that promote abundance in plant communities. Two of these processes are plant functional traits and plant-soil feedback. Plant traits have been proven useful in predicting abundance across many ecosystems due to their reflection of varying resource allocation in different environments. Plant-soil feedback estimates emerge through […]
C10: Determining How Activation of the DNA-Dependent Protein Kinase Impacts Adenovirus Replication
While human adenovirus (Ad) infection can cause severe illness, antiviral treatments often cause serious adverse effects and have limited efficacy against severe Ad infection. Ad infection activates the cellular DNA damage response (DDR), which triggers activation of protein complexes such as the DNA-dependent protein kinase (DNA-PK) that hinder viral infection. However, Ad wields several viral […]
C11: The Fusion of Aerobic and Resistance Exercise: Physiological and Perceptual Responses
To optimize the benefits of exercise training, we tested a novel combined aerobic (AE) & resistance exercise (RE) routine. PURPOSE: To determine if alternating short bouts of RE & AE into one exercise routine or microcycles (MC) of RE & AE results in similar cardiovascular, metabolic & perceptual responses compared to a traditional method of […]
C13: Effectiveness of Diversity, Equity, Inclusion, and Bias Modules at Miami University
Our research project aims to evaluate the effectiveness of the Diversity, Equity, and Inclusion modules given to students before coming to Miami University. Using qualitative and quantitative methods, we explored the opinions of first-year students based on their experience and thoughts while completing the modules. This study is relevant to all fields because diversity education […]
C14: Psychological Impacts of Hearing Impairments
Focusing on diversity equity and inclusion in relation to our group’s majors of Speech Pathology/Audiology, Sociology, and Psychology, we specifically looked at how the quality of life, perception, and mental health were affected in the lives of individuals with hearing impairments. In the context of this study, hearing impairments are defined as mild to profound […]
C15: Decreased Psychological Flexibility Mediation of Body-Related Shame and Insomnia
Experiences of body-related shame are common and impactful on individuals. They are linked to a number of negative health outcomes. Yet, how it relates to sleep quality, an essential health outcome, remains understudied. Moreover, even less is known about potential mechanisms that may explain the link between body-related shame and insomnia. One such mechanism is […]
C16: Investigation of Captopril and QDP-1 for Inhibition of NDM Clinical Variants
This project explores the ability of various compounds to inhibit variants of the New Delhi Metallo-Beta-Lactamase (NDM) enzyme. Metallo-beta-lactamases (MBLs) are enzymatic resistance mechanisms expressed by a growing number of bacteria found to exhibit antibiotic resistance. While other resistance mechanisms can be treated, no clinically-viable inhibitor exists for MBL enzymes. Due to this looming threat, […]
C17: Normal Phase and Reversed Phase Liquid Chromatography Using Dimethylcarbonate as the Mobile Phase Modifier Solvent
A growing focus in the field of green analytical chemistry has been the development of greener solvents. Thus, the idea of replacing toxic solvents used in high performance liquid chromatography (HPLC) has become a priority. Previous work has shown that dimethyl carbonate (DMC) is a useful replacement for acetonitrile in hydrophilic interaction liquid chromatography (HILIC). […]
C18: Role of Hypoxia on Chick Retinal Pigment Epithelium Reprogramming
The retina is one of the most important tissues since it is responsible for sight. Injury to the retina can lead to irreparable visual loss. Therefore, studying the process of retinal regeneration in vertebrates that are capable of doing so is important for understanding how the retina can be healed, instead of scarred, after an […]