In recent years, machine learning and artificial intelligence has found unique applications in a plethora of fields and industries. Specifically, in organic chemistry, machine learning algorithms have been used to predict organic synthesis strategies based on previous patented data. Although the current available programs have shown over 90% accuracy on many common industrial reactions, they […]
A37: Abiotic Proteins: ortho-Phenylene Based Foldamer Cages
Great progress has been made toward the design of secondary structure in abiotic foldamers. However, to mimic the function and behavior of proteins, well defined tertiary structure must be achieved. The self-assembly of foldamers into macrocyclic cages is a simple approach to tertiary structure. The molecular backbone chosen for our foldamer cages is the ortho-phenylenes. […]
A36: Heart Membrane Proteins’ Malfunction Leads to Long- QT Syndrome: Detergent Free Purification of KCNE1 Using Functionalized SMALPS
KCNE1 and KCNQ1 are membrane proteins located in the heart that are responsible for repolarization. Malfunction of these proteins can lead to “Long QT Syndrome”—a condition that can cause life threatening arrhythmia and sudden cardiac death. Styrene maleic acid copolymer lipid nanoparticles (SMALPS) is a membrane mimetic system that purifies a protein and allows for […]
A40: The Role of Skin Deformation in Radial Pulse Measurements
Measured at the terminal region of the wrist, radial pulses provide crucial health information. They have long been used to diagnosis internal diseases in Eastern Medicine. In recent years, wearable healthcare devices (such as wrist worn braces and smart watches) use radial pulses to track the wearer’s activities and vital signs. Thus, accurate measurements of […]
A43: Actinobacteria and Their Link to Unique Microbial Ecosystems in the Taylor Dry Valleys, Antarctica
Extremophiles, organisms that live in environments outside of the conditions that are well suited to life, need incredible amounts of adaptation to survive. One of the most extreme environments on earth are the lakes in the Taylor Dry Valleys in Antarctica. These lakes are subject to the polar night, as well as increased radiation.Low precipitation […]
A31: Effects of Estrogen and Glucose on Colorectal Cancer Cell Growth
Recently in the world, there has been a rapid increase in the prevalence of and mortality from obesity, diabetes mellitus, and colorectal cancer (CRC). Colorectal cancer related deaths have become the second highest category of cancer death in both the U.S. and the world, including roughly 2 million global diagnoses every year and 700,000 CRC […]
A35: Comparing PT Paths of Metamorphic Rocks Determined by Quantitative and Semi-quantitative Approaches: A Case Study from the Monviso Ophiolite, Italy
Historically, the field of metamorphic petrology has advanced largely due to the implementation of techniques for quantifying the chemical compositions of rocks in situ. Today, concentrations of major and trace elements are routinely measured on the micrometer scale with instruments like the Electron Probe Microanalyzer (EPMA) and others. Quantitative chemical maps of minerals produced by […]
A33: What Can Symplectites Tell Us About Geological Processes on the Moon and Mars?
The work presented here reports findings from a detailed microscopic study of symplectites in lunar samples, specifically in basalts from the Apollo 15 mission and meteorites collected from Antarctica in 2018-2019. The symplectites studied are consistently composed of the same three minerals, olivine (olv), clinopyroxene (cpx), and silica (si). They represent the products of breakdown, […]
A34: Deformation of Dry High-pressure Eclogites DuringTectonic Slicing of Subducted Oceanic Lithosphere: A Case Study from the Monviso Ophiolite, Italy
The Alps contain records of deeply subducted oceanic lithosphere that detached at high-pressure (HP) conditions and later exhumed to the surface. These HP ophiolite bodies are key to understanding important geodynamics processes occurring along the plate-interface within subduction zones, yet the nature of their detachment and recovery is not well-understood. For example, HP ophiolites from […]
A28: The Impact of Elevated Salinity on Palmelloid Formation and Disruption in Chlamydomonas Species
Soil salinity is a foreign term to most, yet it is now a global issue. With an increase in farming and irrigation worldwide, soil salinity is stunting crop growth and inhibiting its ability to produce viable yields. Salt exposure to photosynthetic organisms can severely inhibit their growth rate and cause cell damage, however, mesophilic green […]