Glyphosate, the active ingredient in Roundup, is the most commonly used herbicide in American agriculture. The biodegradation of glyphosate leads to aminomethylphosphonic acid (AMPA). Glyphosate and AMPA have been extensively characterized to be toxic to organ development– however, it remains unexplored in cardiac development. Using zebrafish as a model due to their tractability, we examine […]
C13: Characterization of Chamber Specific Heart Morphology and Cell Death in Zebrafish Integrin Mutants
Matthew Heilzer, Devin O’Connor Jennifer Schumacher, Department of Biology Griffin Chadwick, Department of Biology
C01: Molecular analysis of pendulum mutants presenting with defects in heart valve and outflow tract development
Unidirectional blood flow, controlled by valves within the heart, is an essential component for proper and efficient heart function. 30% of patients exhibiting a congenital heart defect present with defects in these valves resulting in decreased heart function. In zebrafish, valve formation occurs at the atrioventricular canal (AVC) and outflow tract (OFT). The signaling pathways […]