Post-traumatic stress disorder (PTSD) and alcohol use disorder (AUD) have a high rate of comorbidity. While this comorbidity is well documented, its neural correlates are still poorly understood. Recent studies have shown that anxiety disorders and AUD are similarly characterized by altered amygdalar structure and activity but less is known about the specific circuits within […]
B45: Determination of Recombination Frequency Between Sexes in a Maize Hybrid
Meiotic recombination ensures the accurate segregation of homologous chromosomes and reshuffles genetic information to generate new combinations of alleles. In plants, recombination is essential for plant breeding, which allows us to map quantitative traits and introduce desirable traits into elite breeding lines. Sex differences have important consequences for population differentiation, sex chromosome evolution, adaptation, and […]
B29: Examining Sex Chromosome and Gonadal Hormone Influences on Fear Learning in Mice
There are known disparities in susceptibility to psychiatric and stress-related disorders between sexes. Post-traumatic stress disorder (PTSD) is one such case. We used stress-enhanced fear learning (SEFL), a validated animal model for PTSD. However, it is unknown if sex differences stem from gonadal (Sry + vs. Sry -) or chromosomal (XX vs. XY) differences. The […]
C70: Sex differences in alcohol seeking behavior in four-core genotype mice
The purpose of our study is to determine whether hormones or chromosomes have a greater impact on the motivation to seek alcohol in a mouse model. Studies have found that sex differences exist for alcohol consumption between both humans and rodents, and female rodents consistently consume more alcohol than males (Füllgrabe et al., 2007). The […]
C69: Influence of Sex in the Alcohol Drinking Behaviors Using the Four Core Genotype Mouse Model
Differences in addiction behavior between the sexes is a topic of great interest in both the behavioral neuroscience field and to the general public. In alcohol use disorder, women often consume greater volumes of alcohol and may be more susceptible to stress-induced relapse. To investigate behaviors such as these and their causes, a transgenic mouse […]
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