Recently, evidence of the paraventricular nucleus of the thalamus (PVT) plays a pivotal role in fear responses. Still, more research is needed into how important PVT is in safety learning. In this study, we examined the role of PVT and its projection to the bed nucleus of the stria terminalis (BNST) in safety learning through […]
CSI-04: Effects of Acute Early Life Stress and CRH2 Receptor Antagonism on Anxiety in Adult Rats
After undergoing an early life stress (ELS) event, susceptibility to fear and anxiety-related disorders becomes more common. Post-traumatic stress disorder (PTSD) and generalized anxiety disorder are often precipitated by ELS experience and can negatively impact one’s life and ability to function. An established reciprocal neural circuit between serotonergic neurons of the dorsal raphe nucleus (DRN) […]
A19: The Role of the Paraventricular Nucleus of the Thalamus in the Expression of Safety Learning
An estimated 70% of the population experiences a traumatic event at some point in their life, and up to 20% of these individuals go on to develop posttraumatic stress disorder (PTSD). PTSD is a debilitating condition that significantly reduces the quality of life and alters an individual’s ability to regulate fear and safety cues. Rodent […]
C35: The Effects of Sex and Early Life Stress on Conditioned Inhibition of Fear in Rodents
Posttraumatic stress disorder (PTSD) is a debilitating condition that occurs in a subset of individuals who experience one or more traumatic events. It is marked by recurrent memories of the traumatic event, heightened anxiety states, altered mood, and avoidance behaviors. Importantly, adverse early childhood experiences yield increased vulnerability to the development of PTSD later in […]
B32: A Role for Serotonin in Mediated Stress Enhanced Fear Learning Following Exposure to Early Life Stress
Rodents provide a useful translational model of fear- and anxiety-related behaviors. Previously stressed animals exhibit physiological and behavioral stress responses that parallel those observed in anxious humans. Patients diagnosed with posttraumatic stress disorder (PTSD) present with a spectrum of debilitating anxiety symptoms that result from exposure to one or more traumatic events, with women having […]