DNA methylation is a critical mechanism for the epigenetic control of tissue differentiation in organisms, particularly when it comes to the development of sperm and testes. There is little information, however, concerning specific methylation patterns and their effects on these regions. One gene of interest is SLC9B1, which codes for NHA1, a sodium-hydrogen exchanger that […]
A54: Characterizing the Role of NHE11 in Mammalian Sperm Physiology Using CRISPR/Cas9 Gene Edited Mice
Sodium Hydrogen Exchangers (NHEs) are a family of proteins which are important for maintaining the pH of a cell. A few NHEs have been found to be essential for the function and fertility of sperm cells. One of these in particular, NHE11, is exclusively expressed in the sperm and testes. NHE11 is also the only […]
A52: Effects of Early Life Physical Inactivity Using the Novel Model of Small Mouse Cage on Growth and Health in Adulthood
Physical activity (PA) is a vital behavior to maximize health and wellness. Less is understood regarding the impact of physical inactivity on children, specifically during key stages of skeletal muscle development. We previously demonstrated that 2 weeks of extreme muscle tissue during 4-6 weeks of age causes a reduction in grip strength in adults (5 […]