{"id":9391,"date":"2024-04-22T10:20:56","date_gmt":"2024-04-22T14:20:56","guid":{"rendered":"https:\/\/sites.miamioh.edu\/undergraduate-research-forum\/?p=9391"},"modified":"2024-06-16T17:49:05","modified_gmt":"2024-06-16T21:49:05","slug":"c56-sex-differences-in-safety-and-threat-learning-an-evaluation-of-bnst-projecting-neurons-from-the-pvt","status":"publish","type":"post","link":"https:\/\/sites.miamioh.edu\/undergraduate-research-forum\/c56-sex-differences-in-safety-and-threat-learning-an-evaluation-of-bnst-projecting-neurons-from-the-pvt\/","title":{"rendered":"C56: Sex Differences in Safety and Threat Learning: An Evaluation of BNST-projecting Neurons From the PVT"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">Recently, evidence of the paraventricular nucleus of the thalamus (PVT) plays a pivotal role in fear responses. Still, more research is needed into how important PVT is in safety learning. In this study, we examined the role of PVT and its projection to the bed nucleus of the stria terminalis (BNST) in safety learning through a sex-dependent lens. This was done by placing retrograde beads into the BNST, training the rats over five days, and overlaying the beads with c-Fos presentation using immunohistochemistry to determine the prevalence of the BNST-PVT pathway in safety learning. The behavioral training included the first two days of habituation followed by two days of presentations of the conditioned stimulus, and on the last day, the rats were exposed to the context or the context and safety cue. Our findings show that there was no significant main effect for freezing in males and females for sex, test type, and sex by test type. Microscopy and Imagery of these brain regions are still ongoing. These results have unique implications for future research in the realms of fear learning and PTSD.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Authors: <strong>Luke Koulouris<\/strong>, Business Economics and Premedical Studies Major<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Hannah Ledbetter<\/strong>, Psychology and Computer Science Major<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Devon Hobbs<\/strong>, Psychology Major<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Chloe Hudock<\/strong>, Psychology and Neuroscience Major<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Advisor(s): Jennifer Quinn, Department of Psychology<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Amanda Reichert, Department of Psychology<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">August Ogunnowo, Department of Psychology<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Recently, evidence of the paraventricular nucleus of the thalamus (PVT) plays a pivotal role in fear responses. Still, more research is needed into how important PVT is in safety learning. In this study, we examined the role of PVT and its projection to the bed nucleus of the stria terminalis (BNST) in safety learning through [&hellip;]<\/p>\n","protected":false},"author":301,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_bbp_topic_count":0,"_bbp_reply_count":0,"_bbp_total_topic_count":0,"_bbp_total_reply_count":0,"_bbp_voice_count":0,"_bbp_anonymous_reply_count":0,"_bbp_topic_count_hidden":0,"_bbp_reply_count_hidden":0,"_bbp_forum_subforum_count":0,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"jetpack_post_was_ever_published":false},"categories":[1589,1,1602,52],"tags":[98,1649,661,1136,89],"class_list":["post-9391","post","type-post","status-publish","format-standard","hentry","category-2024-posters","category-projects","category-51-60","category-psychology","tag-neuroscience","tag-pre-medical-studies","tag-psychology","tag-ptsd","tag-stem"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/pbRpLx-2rt","jetpack_likes_enabled":true,"_links":{"self":[{"href":"https:\/\/sites.miamioh.edu\/undergraduate-research-forum\/wp-json\/wp\/v2\/posts\/9391","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.miamioh.edu\/undergraduate-research-forum\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sites.miamioh.edu\/undergraduate-research-forum\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sites.miamioh.edu\/undergraduate-research-forum\/wp-json\/wp\/v2\/users\/301"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.miamioh.edu\/undergraduate-research-forum\/wp-json\/wp\/v2\/comments?post=9391"}],"version-history":[{"count":0,"href":"https:\/\/sites.miamioh.edu\/undergraduate-research-forum\/wp-json\/wp\/v2\/posts\/9391\/revisions"}],"wp:attachment":[{"href":"https:\/\/sites.miamioh.edu\/undergraduate-research-forum\/wp-json\/wp\/v2\/media?parent=9391"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sites.miamioh.edu\/undergraduate-research-forum\/wp-json\/wp\/v2\/categories?post=9391"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sites.miamioh.edu\/undergraduate-research-forum\/wp-json\/wp\/v2\/tags?post=9391"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}