{"id":8069,"date":"2023-04-17T23:00:46","date_gmt":"2023-04-18T03:00:46","guid":{"rendered":"https:\/\/sites.miamioh.edu\/undergraduate-research-forum\/?p=8069"},"modified":"2023-04-17T23:00:46","modified_gmt":"2023-04-18T03:00:46","slug":"a37-abiotic-proteins-ortho-phenylene-based-foldamer-cages","status":"publish","type":"post","link":"https:\/\/sites.miamioh.edu\/undergraduate-research-forum\/a37-abiotic-proteins-ortho-phenylene-based-foldamer-cages\/","title":{"rendered":"A37: Abiotic Proteins: ortho-Phenylene Based Foldamer Cages"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">Great progress has been made toward the design of secondary structure in abiotic foldamers.&nbsp; However, to mimic the function and behavior of proteins, well defined tertiary structure must be achieved.&nbsp; The self-assembly of foldamers into macrocyclic cages is a simple approach to tertiary structure.&nbsp; The molecular backbone chosen for our foldamer cages is the ortho-phenylenes.&nbsp; The ortho-phenylenes are desirable given that their folding in solution can be characterized in detail using NMR spectroscopy.&nbsp; The assembly of ortho-phenylene hexamers or decamers with one of three vertices to give [2+3] cages through imine condensation has been studied.&nbsp; Each vertex has a different bite angle, which forces folding into different conformations. Due to the complex geometric structure of the desired cage, the question of interaction between folding and self-assembly is to be investigated. Optimization of the formation conditions and characterization of the [2+3] foldamer cage will be discussed.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Author(s): Marissa Fornadel, Chemistry and Environmental Science Major<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Advisor(s): Scott Hartley, Department of Chemistry and Biochemistry<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Roshan Lama, Department of Chemistry and Biochemistry<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" width=\"720\" height=\"540\" data-attachment-id=\"8071\" data-permalink=\"https:\/\/sites.miamioh.edu\/undergraduate-research-forum\/a37-abiotic-proteins-ortho-phenylene-based-foldamer-cages\/a37-slide01-1\/\" data-orig-file=\"https:\/\/i0.wp.com\/sites.miamioh.edu\/undergraduate-research-forum\/files\/2023\/04\/A37-Slide01-1.png?fit=720%2C540&amp;ssl=1\" data-orig-size=\"720,540\" data-comments-opened=\"0\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;0&quot;}\" data-image-title=\"A37-Slide01-1\" data-image-description=\"\" data-image-caption=\"\" data-large-file=\"https:\/\/i0.wp.com\/sites.miamioh.edu\/undergraduate-research-forum\/files\/2023\/04\/A37-Slide01-1.png?fit=720%2C540&amp;ssl=1\" src=\"https:\/\/i0.wp.com\/sites.miamioh.edu\/undergraduate-research-forum\/files\/2023\/04\/A37-Slide01-1.png?resize=720%2C540&#038;ssl=1\" alt=\"Abiotic Proteins: ortho-Phenylene Based Foldamer Cages\" class=\"wp-image-8071\" srcset=\"https:\/\/i0.wp.com\/sites.miamioh.edu\/undergraduate-research-forum\/files\/2023\/04\/A37-Slide01-1.png?w=720&amp;ssl=1 720w, https:\/\/i0.wp.com\/sites.miamioh.edu\/undergraduate-research-forum\/files\/2023\/04\/A37-Slide01-1.png?resize=300%2C225&amp;ssl=1 300w, https:\/\/i0.wp.com\/sites.miamioh.edu\/undergraduate-research-forum\/files\/2023\/04\/A37-Slide01-1.png?resize=600%2C450&amp;ssl=1 600w\" sizes=\"auto, (max-width: 720px) 100vw, 720px\" \/><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Great progress has been made toward the design of secondary structure in abiotic foldamers.&nbsp; However, to mimic the function and behavior of proteins, well defined tertiary structure must be achieved.&nbsp; The self-assembly of foldamers into macrocyclic cages is a simple approach to tertiary structure.&nbsp; The molecular backbone chosen for our foldamer cages is the ortho-phenylenes.&nbsp; [&hellip;]<\/p>\n","protected":false},"author":301,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_bbp_topic_count":0,"_bbp_reply_count":0,"_bbp_total_topic_count":0,"_bbp_total_reply_count":0,"_bbp_voice_count":0,"_bbp_anonymous_reply_count":0,"_bbp_topic_count_hidden":0,"_bbp_reply_count_hidden":0,"_bbp_forum_subforum_count":0,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":false,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"jetpack_post_was_ever_published":false},"categories":[1300,1304,1,27],"tags":[906,1489,89],"class_list":["post-8069","post","type-post","status-publish","format-standard","hentry","category-2023-posters","category-a31-40","category-projects","category-chemistry-biochemistry","tag-chemistry","tag-organic-chemistry","tag-stem"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/pbRpLx-269","jetpack_likes_enabled":true,"_links":{"self":[{"href":"https:\/\/sites.miamioh.edu\/undergraduate-research-forum\/wp-json\/wp\/v2\/posts\/8069","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.miamioh.edu\/undergraduate-research-forum\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sites.miamioh.edu\/undergraduate-research-forum\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sites.miamioh.edu\/undergraduate-research-forum\/wp-json\/wp\/v2\/users\/301"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.miamioh.edu\/undergraduate-research-forum\/wp-json\/wp\/v2\/comments?post=8069"}],"version-history":[{"count":0,"href":"https:\/\/sites.miamioh.edu\/undergraduate-research-forum\/wp-json\/wp\/v2\/posts\/8069\/revisions"}],"wp:attachment":[{"href":"https:\/\/sites.miamioh.edu\/undergraduate-research-forum\/wp-json\/wp\/v2\/media?parent=8069"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sites.miamioh.edu\/undergraduate-research-forum\/wp-json\/wp\/v2\/categories?post=8069"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sites.miamioh.edu\/undergraduate-research-forum\/wp-json\/wp\/v2\/tags?post=8069"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}