{"id":714,"date":"2020-04-23T22:30:59","date_gmt":"2020-04-24T02:30:59","guid":{"rendered":"https:\/\/sites.miamioh.edu\/undergraduate-research-forum\/?p=714"},"modified":"2020-04-27T16:24:54","modified_gmt":"2020-04-27T20:24:54","slug":"poster-copper-catalyzed-deaminative-difluoromethylation","status":"publish","type":"post","link":"https:\/\/sites.miamioh.edu\/undergraduate-research-forum\/poster-copper-catalyzed-deaminative-difluoromethylation\/","title":{"rendered":"B29: Copper-Catalyzed Deaminative Difluoromethylation"},"content":{"rendered":"

A difluoromethyl group (CF2H) is considered to be a lipophilic and metabolically stable bioisostere of an amino (NH2) group. Therefore, methods that can directly convert a NH2 group into a CF2H group would be of great value to medicinal chemistry. We report an efficient Cu-catalyzed approach for the conversion of alkyl pyridinium salts, which can be readily synthesized from the corresponding alkyl amines, to their alkyl difluoromethane analogues. This protocol tolerates a broad range of functional groups and can be applied to late-stage modification of complex amino-containing pharmaceuticals.<\/p>\n

Authors:<\/strong> Samson B. Zacate<\/p>\n

Faculty Advisor:<\/strong> Dr. Wei Liu, Chemistry and Biochemistry<\/p>\n

Xiaojun Zeng, Wenhao Yan, Aijie Cai, Yufei Wang, Dongqi Yang, Kundi Yang, Wei Liu<\/p>\n

\"\"<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

A difluoromethyl group (CF2H) is considered to be a lipophilic and metabolically stable bioisostere of an amino (NH2) group. Therefore, methods that can directly convert a NH2 group into a CF2H group would be of great value to medicinal chemistry. We report an efficient Cu-catalyzed approach for the conversion of alkyl pyridinium salts, which can […]<\/p>\n","protected":false},"author":2899,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_bbp_topic_count":0,"_bbp_reply_count":0,"_bbp_total_topic_count":0,"_bbp_total_reply_count":0,"_bbp_voice_count":0,"_bbp_anonymous_reply_count":0,"_bbp_topic_count_hidden":0,"_bbp_reply_count_hidden":0,"_bbp_forum_subforum_count":0,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"jetpack_post_was_ever_published":false},"categories":[10,27],"tags":[195,89,194],"class_list":["post-714","post","type-post","status-publish","format-standard","hentry","category-2020-posters","category-chemistry-biochemistry","tag-catalysis","tag-stem","tag-synthesis"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/pbRpLx-bw","jetpack_likes_enabled":true,"_links":{"self":[{"href":"https:\/\/sites.miamioh.edu\/undergraduate-research-forum\/wp-json\/wp\/v2\/posts\/714","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.miamioh.edu\/undergraduate-research-forum\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sites.miamioh.edu\/undergraduate-research-forum\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sites.miamioh.edu\/undergraduate-research-forum\/wp-json\/wp\/v2\/users\/2899"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.miamioh.edu\/undergraduate-research-forum\/wp-json\/wp\/v2\/comments?post=714"}],"version-history":[{"count":0,"href":"https:\/\/sites.miamioh.edu\/undergraduate-research-forum\/wp-json\/wp\/v2\/posts\/714\/revisions"}],"wp:attachment":[{"href":"https:\/\/sites.miamioh.edu\/undergraduate-research-forum\/wp-json\/wp\/v2\/media?parent=714"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sites.miamioh.edu\/undergraduate-research-forum\/wp-json\/wp\/v2\/categories?post=714"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sites.miamioh.edu\/undergraduate-research-forum\/wp-json\/wp\/v2\/tags?post=714"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}