From Insulin Regulation to Appetite Suppression: How Metformin Helps You Lose Weight without Diabetes – 8 Reasons

If you’re looking for a weight loss supplement that can help you lose weight without diabetes, metformin may be the answer. The drug is commonly prescribed to people with type 2 diabetes and prediabetes, but it’s also used as an off-label treatment for other conditions like metabolic syndrome and polycystic ovary syndrome. A 2012 study showed that at least 50 percent of people taking metformin experience some form of weight loss—and even more importantly, they don’t gain it back once they stop taking the medication! Keep reading to learn more about how this common drug can help you achieve your ideal body weight.

Metformin weight loss not diabetic

The metformin weight loss not diabetic is that the drug acts directly to lower insulin resistance and reduce fat accumulation in the liver. Metformin may also decrease appetite, resulting in reduced food intake.

Metformin does not cause hypoglycemia, or low blood sugar levels, because it does not work directly on the pancreas to release insulin. Instead, it works by boosting the activity of the cells in your liver and muscles that produce glucose (sugar).

metformin weight loss not diabetic
metformin weight loss not diabetic

1. Helps Regulate Your Insulin Levels

Metformin is a biguanide, which means it helps regulate your insulin levels. Metformin lowers blood sugar by reducing insulin resistance, a condition where your body doesn’t respond properly to the hormone insulin. In other words, metformin helps your body use glucose (sugar) as energy instead of storing it as fat.

Metformin is the most commonly prescribed medication for type 2 diabetes; about half of all people with type 2 diabetes take this drug daily. This is because it’s been shown to reduce or prevent complications associated with high blood sugar levels–including nerve damage and kidney disease–and increase life expectancy in people with diabetes by about four years compared with those who don’t take any medications at all

2. Suppresses Your Appetite

Metformin can also reduce appetite. Researchers think this is because it increases serotonin levels in the brain, which helps regulate appetite. Serotonin is a neurotransmitter that plays a role in mood and depression, but it’s also thought to play an important role in regulating your desire to eat. If you have diabetes or obesity, chances are good that your body isn’t producing enough serotonin on its own–and metformin may help make up for that deficit.

One study found that obese people who took metformin lost more weight than those who didn’t take the drug (22 pounds versus 13 pounds). In fact, some studies have even shown that taking metformin alongside other medications like sibutramine (meridia) can produce even better results than either drug alone!

3. May Help Prevent the Onset of Type 2 Diabetes

Metformin also has been shown to reduce the risk of developing type 2 diabetes. In a study published in The Lancet, researchers found that patients who took metformin were less likely to develop type 2 diabetes than those who did not take it.

The results? Those taking metformin had an 11% lower risk of developing type 2 diabetes compared with those who didn’t take it. Another study showed that patients taking metformin had a 31% reduced risk and those with high blood sugar levels saw their risk decrease by 60%.

Metformin is one of the most commonly prescribed oral medications for pre-diabetes or borderline diabetes because it helps maintain normal blood glucose levels while helping manage weight loss efforts as well as improve insulin sensitivity (which means your body uses insulin more efficiently).

4. Supports Healthy Mitochondria Function

Metformin may help you lose weight without diabetes by improving mitochondrial function. Mitochondria are the powerhouses of your cells, and they burn fat and produce energy. As we age, our mitochondria become less efficient at doing their job–and this can lead to a higher BMI and increased risk for obesity-related diseases like type 2 diabetes.

Metformin has been shown to improve mitochondrial function in obese mice with impaired glucose tolerance (IGT), which is similar to pre-diabetes in humans. In fact, one study found that metformin reduced body weight gain by 25% compared with control rats fed normal chow diets!

5. Improves Your Immune System

Another benefit of taking metformin is that it can improve your immune system. Your body’s ability to fight infections and cancer depends on a strong immune system, so this is a great way to help yourself lose weight without diabetes.

In addition, studies have shown that people who take metformin are less likely than others to get sick with upper respiratory tract infections like bronchitis or pneumonia.[1] This may be because metformin increases the production of white blood cells (specifically neutrophils) which help fight off bacteria and viruses.[2]

6. May Improve Fatty Liver Disease Symptoms

Metformin may also help improve fatty liver disease symptoms. Fatty liver disease is when excess fat builds up in your liver, causing inflammation and damage to the organ.

Metformin can reduce liver fat by up to 20% after just 12 weeks of treatment, according to one study published in Diabetes Care in 2007. This effect was seen even when patients weren’t obese or overweight–they simply had elevated levels of triglycerides (blood fats) that indicated they were at risk for developing diabetes or cardiovascular disease.

The drug also improved insulin sensitivity, which could explain why it helps lower cholesterol levels as well as triglycerides; improved insulin sensitivity means that cells take up glucose more efficiently from the bloodstream after eating a meal.*

In addition, metformin has been shown to reduce inflammation throughout the body and protect against oxidative stress.*

7. Modulates Gut Bacteria Populations and Microbiome Diversity

Metformin may help you lose weight by improving the diversity of your gut bacteria, which plays a role in regulating metabolism. Gut bacteria populations are known to be associated with obesity and diabetes, so it’s important to maintain healthy levels of them if you want to keep your weight down.

The way that metformin helps improve this is by inhibiting an enzyme called adenosine monophosphate-activated protein kinase (AMPK). This enzyme triggers insulin secretion from beta cells in our pancreas when we eat food; however, when AMPK activity is reduced it slows down this process so less insulin is released into circulation at once — thus reducing blood sugar levels after meals while also reducing fat storage.

Metformin may help you lose weight without diabetes by regulating insulin, suppressing appetite and improving your microbiome

Metformin is also the most widely used drug in the world, with over 50 million prescriptions filled annually. It’s been shown to be effective at reducing body weight, especially when combined with lifestyle intervention (like a healthy diet and exercise).

In addition to its ability to regulate insulin levels, metformin may also suppress appetite by activating AMPK–a protein that plays a role in regulating energy metabolism–and increasing GLP-1 secretion from your gut. Both of these mechanisms have been linked to reduced hunger cravings and increased satiety after meals.

Metformin, a drug used to treat type 2 diabetes, has long been known to have weight loss benefits. But now researchers are discovering that metformin may help you lose weight without diabetes by regulating insulin, suppressing appetite and improving your microbiome.

Metformin can be prescribed alone or in combination with other medications to treat type 2 diabetes. The drug works by activating AMP-activated protein kinase (AMPK), which decreases glucose production in the liver and increases glucose uptake into cells.

Metformin is one of the most widely prescribed drugs in the world, but its use has been limited in the United States because it can cause lactic acidosis — a buildup of lactate in the blood — especially if combined with certain other drugs such as aspirin or alcohol. A recent large clinical trial found no increased risk of death from taking metformin compared with placebo.

The drug has been studied for its ability to improve weight loss outcomes for people with type 2 diabetes. It was also shown to assist with weight loss in nondiabetics who took it for 12 weeks at a dose of 850 milligrams twice daily before meals or 850 milligrams once daily after breakfast and lunch combined with diet and exercise counseling sessions.


Metformin is a great option if you want to lose weight without diabetes. It’s been shown to be effective in many different studies and has few side effects compared with other medications. If you’re interested in trying this medication or any other, talk with your doctor about which options would be best for your situation!