{"id":186,"date":"2017-02-21T11:35:05","date_gmt":"2017-02-21T16:35:05","guid":{"rendered":"http:\/\/sites.miamioh.edu\/cricket-lab\/?page_id=186"},"modified":"2017-11-21T10:34:55","modified_gmt":"2017-11-21T15:34:55","slug":"fragile-x-project","status":"publish","type":"page","link":"https:\/\/sites.miamioh.edu\/cricket-lab\/sample-page\/fragile-x-project\/","title":{"rendered":"Fragile X Project"},"content":{"rendered":"<p style=\"text-align: left\">Fragile X syndrome is the most common form of inherited mental retardation caused by a mutation in the regulatory region of the gene. This mutation increases the number of CGG repeats, which leads to hyper-methylation and transcriptional silencing, and ultimately the loss of the gene product Fragile X Mental Retardation Protein (FMRP).\u00a0 This deficit leads to small, immature neuronal spines that lack synapses, thereby reducing synaptic plasticity. Mutations in Fragile X can also impact the function of neural stem cells, causing learning deficits and decreased adult neurogenesis. Our goal is to determine how FMRP regulates adult neurogenesis using the cricket as a simple model<em>. <\/em>We are using RNA interference to reduce the expression of Fragile X and examining how this impacts adult neurogenesis, the ultrastructure of the niche, social behavior, immune function, and learning and memory.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-519 size-full\" src=\"http:\/\/sites.miamioh.edu\/cricket-lab\/files\/2017\/02\/In-situe-behavior-and-Ghosal-K.-Gupta-M.-and-Killian-K.-A.-2010-J.-Exp.-Biol.-212-2045\u20132056.jpg\" alt=\"\" width=\"1888\" height=\"856\" srcset=\"https:\/\/sites.miamioh.edu\/cricket-lab\/files\/2017\/02\/In-situe-behavior-and-Ghosal-K.-Gupta-M.-and-Killian-K.-A.-2010-J.-Exp.-Biol.-212-2045\u20132056.jpg 1888w, https:\/\/sites.miamioh.edu\/cricket-lab\/files\/2017\/02\/In-situe-behavior-and-Ghosal-K.-Gupta-M.-and-Killian-K.-A.-2010-J.-Exp.-Biol.-212-2045\u20132056-300x136.jpg 300w, https:\/\/sites.miamioh.edu\/cricket-lab\/files\/2017\/02\/In-situe-behavior-and-Ghosal-K.-Gupta-M.-and-Killian-K.-A.-2010-J.-Exp.-Biol.-212-2045\u20132056-768x348.jpg 768w, https:\/\/sites.miamioh.edu\/cricket-lab\/files\/2017\/02\/In-situe-behavior-and-Ghosal-K.-Gupta-M.-and-Killian-K.-A.-2010-J.-Exp.-Biol.-212-2045\u20132056-1024x464.jpg 1024w, https:\/\/sites.miamioh.edu\/cricket-lab\/files\/2017\/02\/In-situe-behavior-and-Ghosal-K.-Gupta-M.-and-Killian-K.-A.-2010-J.-Exp.-Biol.-212-2045\u20132056-772x350.jpg 772w, https:\/\/sites.miamioh.edu\/cricket-lab\/files\/2017\/02\/In-situe-behavior-and-Ghosal-K.-Gupta-M.-and-Killian-K.-A.-2010-J.-Exp.-Biol.-212-2045\u20132056-150x68.jpg 150w\" sizes=\"auto, (max-width: 1888px) 100vw, 1888px\" \/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Fragile X syndrome is the most common form of inherited mental retardation caused by a mutation in the regulatory region of the gene. This mutation increases the number of CGG repeats, which leads to hyper-methylation and transcriptional silencing, and ultimately the loss of the gene product Fragile X Mental Retardation \u2026 <a class=\"continue-reading-link\" href=\"https:\/\/sites.miamioh.edu\/cricket-lab\/sample-page\/fragile-x-project\/\"> Continue reading<\/a><\/p>\n","protected":false},"author":1974,"featured_media":0,"parent":2,"menu_order":4,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_bbp_topic_count":0,"_bbp_reply_count":0,"_bbp_total_topic_count":0,"_bbp_total_reply_count":0,"_bbp_voice_count":0,"_bbp_anonymous_reply_count":0,"_bbp_topic_count_hidden":0,"_bbp_reply_count_hidden":0,"_bbp_forum_subforum_count":0,"footnotes":""},"class_list":["post-186","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/sites.miamioh.edu\/cricket-lab\/wp-json\/wp\/v2\/pages\/186","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.miamioh.edu\/cricket-lab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.miamioh.edu\/cricket-lab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.miamioh.edu\/cricket-lab\/wp-json\/wp\/v2\/users\/1974"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.miamioh.edu\/cricket-lab\/wp-json\/wp\/v2\/comments?post=186"}],"version-history":[{"count":0,"href":"https:\/\/sites.miamioh.edu\/cricket-lab\/wp-json\/wp\/v2\/pages\/186\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/sites.miamioh.edu\/cricket-lab\/wp-json\/wp\/v2\/pages\/2"}],"wp:attachment":[{"href":"https:\/\/sites.miamioh.edu\/cricket-lab\/wp-json\/wp\/v2\/media?parent=186"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}